Seminarium „Kwasy nukleinowe zawierające fluor – synteza i zastosowania”

Serdecznie zapraszamy na seminarium Koła Nukleotyd, które odbędzie się w sali 5004 na V piętrze Centrum Nowych Technologii. W czwartek o godzinie 17:00 wystąpi Marek Baranowski.

 

Kwasy nukleinowe zawierające fluor – synteza i zastosowania

Fluorowane nukleozydy były przedmiotem badań już w latach 50-tych kiedy odkryto ich właściwości antybakteryjne i przeciwnowotworowe (nukleocydyna, 5-fluorouracyl). Pegaptanib, zatwierdzony w 2004 roku przez FDA lek, jest aptamerem zawierającym w swojej strukturze modyfikację 2’F. Oprócz zastosowań medycznych, fluorowane nukleotydy/kwasy nukleinowe znalazły swoje zastosowania jako sondy molekularne w badaniach 19F NMR. Na seminarium opowiem o metodach syntezy kwasów nukleinowych zawierających atom/y fluoru oraz krótko wskażę zastosowania tych związków w połączeniu z techniką fluorowego magnetycznego rezonansu jądrowego.

 

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