Seminarium „Identification of allosteric inhibitors of the ecto-5’-nucleotidase (CD73) targeting the dimer interface”

Serdecznie zapraszamy na seminarium Koła Nukleotyd. Dzisiaj o godzinie 17:00 wystąpi Mateusz Kozarski.

Tytuł: Identification of allosteric inhibitors of the ecto-5’-nucleotidase (CD73) targeting the dimer interface

Abstrakt: 5’-nukleotydazy to białka pełniące kluczową rolę w metabolizmie nukleotydów. Białka te katalizują reakcję defosforylacji niecyklicznych 5’-monofosofranów nukleozydów do nieorganicznego fosforanu oraz odpowiedniego nukleozydu. Nadaktywność 5’-nukleotydaz została skorelowana z wieloma chorobami (np. Nowotworami). 5’-nukleotydazy biorą również udział w dezaktywacji leków pochodzenia nukleotydowego. Z tego powodu stały się one celem terapeutycznym m.in. w leczeniu chorób nowotworowych. Na czwartkowym seminarium opowiem Wam o specyficznej 5’-nukleotydazie: Ekto 5’-nukleotydazie. Opowiem jaka jest rola tego enzymu w komórce, gdzie występuje oraz nieco o jego inhibitorach.

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