W dniach 26-30 sierpnia 2018 roku, w La Jolla nieopodal San Diego, Kalifornia w Stanach Zjednoczonych Ameryki odbyła się XXIII międzynarodowa konferencja poświęcona najnowszym i najciekawszym odkryciom w dziedzinach chemii i biologii kwasów nukleinowych – International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. Członkowie Koła Naukowego Chemii Biologicznej „Nukleotyd” mieli zaszczyt reprezentować Uniwersytet Warszawski podczas tej konferencji na kampusie Uniwersytetu Kalifornijskiego w San Diego, nad samym brzegiem Oceanu Spokojnego.
Już po przybyciu do celu, mieliśmy okazję zapoznać się z amerykańską kulturą i unikalnym klimatem nadmorskiej metropolii. Po wycieczce po Old Town oraz aklimatyzacji wynikającej z siedmiogodzinnej różnicy czasu, wraz z pozostałymi uczestnikami przystąpiliśmy do intensywnego udziału w konferencji. W przeciągu niespełna czterech dni wysłuchaliśmy 44 wykładów znamienitych badaczy z całego świata oraz prowadziliśmy żywe dyskusje przy plakatach, z których sami przedstawialiśmy 5. Wśród prezentujących, naszą uwagę w szczególności przyciągnęli:
Oliwia Schmidt (University of Zurich, Szwajcaria) – badaczka zajmuje się głównie oddziaływaniami kationów metali z zasadami purynowymi lub pirymidynowymi w podwójnych helisach DNA. Podczas swojej prezentacji opisywała niekanoniczne połączenia pomiędzy zasadami, w których uczestniczyły kationy rtęci lub srebra. Badacze odkryli i opisali zupełnie nowe konformacje takich adduktów oraz wiążące się z nimi implikacje przy dalszym badaniu struktury DNA.
Yajun Wang (Uniwersytet Kolumbii Brytyjskiej, Vancouver, Kanada) – w prezentacji przedstawione zostały niedawne odkrycia dotyczące niezależnych od kationów magnezu DNAzymów (tj. cząsteczek katalizujących reakcje chemiczne zbudowanych z DNA) zawierających zmodyfikowane nukleotydy. Badacz opisywał ich potencjał jako wysoce specyficznych terapeutyków oraz przedstawiał ich potencjalny udział w powstaniu życia na ziemi.
Michael J. Sofia (Arbutus Biopharma, USA) – prezentował drogę do powstania nukleotydowego leku przeciwwirusowego – Sofosbuviru. Był to pierwszy nieinterferonowy lek przeciwko wirusowemu zapaleniu wątroby typu C oraz pierwowzór do syntezy nowatorskich leków przeciwko wirusowi WZW typu B. Badacz opowiadał o problemach ze znalezieniem terapii oraz trwającej ponad 20 lat drodze dążącej do wyeliminowania tej groźnej choroby dotykającej setki tysięcy ludzi na całym swiecie.
Podczas jednej z sesji wystąpiła dr Joanna Kowalska z Instytutu Fizyki Doświadczalnej Wydziału Fizyki Uniwersytetu Warszawskiego. Badania, o których opowiadała dotyczyły jednego z największych odkryć polskiej nauki – dinukleotydów modyfikowanych w obrębie mostka trójfosforanowego o wysokim potencjale do zastosowania w tzw. szczepionkach mRNA oraz najnowszym wynalazku – β-S-ARCA. Wykład spotkał się z wysokim uznaniem publiczności oraz duża ilością pytań członków międzynarodowego środowiska naukowego. Dodatkowym akcentem było wymienienie części członków naszego koła jako wolontariuszy współpracujących przy badaniach.
Plakaty zaprezentowane przez członków koła „Nukleotyd” zawierały wyniki prac badawczych dwóch ówczesnych magistrantów oraz trzech licencjuszy:
Beata Jagoda Starek – „Graphene oxide as fluorescence quencher – developing HTS method for studies on mRNA 5’-end-interacting proteins”
Olga Perzanowska – „Gold nanoparticle-nucleotide conjugates as molecular probes for monitoring activity of cap-binding proteins”
Mateusz Kozarski – „Synthesis of novel m7GMP analogues and evaluation as the inhibitors of cNIIIB nucleotidase”
Sebastian Gołojuch – „Novel phosphoramidate and thiophosphoramidate cap analogs as potential pronucleotide translation inhibitors”
Teodor Olejko – „Synthesis of cleavage-resistant, fluorescentlly labeled cap analogue as a molecular probe for screening potential inhibitors of human Decapping Scavenger”
Udział w konferencji był możliwy dzięki wsparciu Ministerstwa Nauki i szkolnictwa Wyższego dla projektu „Poszerzenie wiedzy oraz prezentacja wyników badań z zakresu chemii i biologii nukleotydów oraz kwasów nukleinowych poprzez udział członków Koła Naukowego Chemii Biologicznej „Nukleotyd” w międzynarodowych konferencjach naukowych” realizowanego w ramach projektu pozakonkursowego „Najlepsi z Najlepszych! 3.0″ w ramach Programu Operacyjnego Wiedza Edukacja Rozwój.
Postaramy się Wam przybliżyć niektóre z omawianych na konferencji zagadnień w czasie najbliższych seminariów Koła Chemii Biologicznej „Nukleotyd”.
Teodor Olejko
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