Seminarium „Targeting the STING pathway – czyli jak wykorzystać cykliczne dinukleotydy w medycynie”

Serdecznie zapraszamy na seminarium Koła Nukleotyd. Dzisiaj o godzinie 17:00 wystąpi Radosław Wójcik.
 
Temat: Targeting the STING pathway – czyli jak wykorzystać cykliczne dinukleotydy w medycynie
 
Abstrakt: Interferony to rozbudowana grupa białek wytwarzanych i uwalnianych przez komórki, jako odpowiedź na obecność patogenów (od wirusów poprzez pasożyty na komórkach nowotworowych kończąc). Niedawne badania wykazały związek między aktywnością białka stymulującego geny interferonowe (STING, STimulator of INterferon Genes) a obecnością cyklicznych dinukleotydów w cytoplazmie komórki. Odkrycie tej zależności zapoczątkowało poszukiwania nowych, nienaturalnych cyklicznych dinukleotydów, które mogą stanowić substraty dla celu terapeutycznego jakim jest STING. Na dzisiejszym seminarium pokrótce opowiem wam o działaniu ścieżki białka STING i wynikach przeprowadzonych poszukiwań nowych substratów.
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